Nilotinib & perantaraannya
High-quality Bahan Perantaraan Kimia supplied by Jinan Shenghe Chemical Co., Ltd. Competitive pricing, reliable delivery, and full technical support for B2B buyers worldwide.
Specifications
| Molecular Formula | C28H22F3N7O |
|---|---|
| Molecular Weight | 529.5158 |
Detailed Chemical Properties & Synonyms
Direct from the manufacturer. Jinan Shenghe Chemical Co., Ltd. supplies this product under ISO-controlled quality with full COA / MSDS / TDS documentation and flexible OEM packaging for global B2B buyers.
Nilotinib & perantaraannya · CAS 641571-10-0 · dibekalkan oleh Jinan Shenghe Chemical Co., Ltd.
Penerangan
Nilotinib & its intermediates · CAS 641571-10-0 · C28H22F3N7O. UNII F41401512X. Keterlarutan: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.
Pengenalan
| CAS Nombor Pendaftaran | 641571-10-0 |
|---|---|
| PubChem CID | 644241 |
| Formula molekul | C28H22F3N7O |
| IUPAC nama | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide |
| UNII (FDA) | F41401512X |
Deskriptor Berkomputer
| Berat Molekul | 529.5 |
|---|---|
| XLogP3 | 4.9 |
| Kiraan Penderma Bon Hidrogen | 2 |
| Kiraan Penerima Bon Hidrogen | 9 |
| Kira Bon Boleh Putar | 6 |
| Jisim Tepat | 529.18379284 |
| Jisim Monoisotop | 529.18379284 |
| Kawasan Permukaan Kutub Topologi | 97.6 |
| Bilangan Atom Berat | 39 |
| Caj Rasmi | 0 |
Fizikal & Sifat Kimia
| Keterlarutan | 2.01e-03 g/L |
|---|---|
| Pemalar Pemisahan | pKa1 = 2.1; pKa2 = 5.4 |
Penerangan fizikal & pengendalian nota
- Solid
- White to slightly yellowish to slightly greenish yellow powder
- Keterlarutan … dalam larutan akueus berkurangan dengan peningkatan pH
- A monohydrate monohydrochloride
- Nilotinib ialah perencat transduksi yang mensasarkan BCR-ABL, c-kit dan PDGF, untuk rawatan berpotensi pelbagai leukemia, termasuk leukemia myeloid kronik (CML).
- Nilotinib preparations: (AHFS, 2010):
GHS Klasifikasi Bahaya
| Penyataan bahaya yang dilaporkan | H361 (69.2%), H372 (15.4%), H373 (76.9%), H400 (69.2%), H410 (69.2%), H413 (23.1%) |
|---|
H361 (69.2%): Disyaki merosakkan kesuburan atau anak dalam kandungan [Ketoksikan Reproduktif Amaran]
H361fd (46.2%): Disyaki merosakkan kesuburan; Disyaki merosakkan anak dalam kandungan [Amaran Reproductive toxicity]
Kegunaan Berdokumen
- Use (kg; approx.) in Germany (2009): >75
- Consumption (g per capita; approx.) in Germany (2009): 0.000916
- Untuk rawatan berpotensi pelbagai leukemia, termasuk leukemia myeloid kronik (CML).
- Nilotinib adalah perencat reseptor tyrosine kinase terpilih yang digunakan dalam terapi leukemia myelogenous kronik. Terapi nilotinib dikaitkan dengan peningkatan sementara dalam paras aminotransferase serum dan kejadian jarang berlaku kecederaan hati akut yang jelas secara klinikal.
- Breast Feeding; Lactation; Milk, Human; Antineoplastic Agents; Enzyme Inhibitors; Protein Kinase Inhibitors; Signal Transduction Inhibitors; Tyrosine Kinase Inhibitors
- Oral – Solid – capsule: 150 mg; 200 mg
Sinonim
Nilotinib; 641571-10-0; AMN 107; AMN-107; nilotinibum; Danziten; NSC-747599; DTXSID5042663; F41401512X; CHEBI:52172; RefChem:58968; AMN 107 Base; DTXCID3022663; L01XE08; Tasigna; AMN107
Soalan Lazim
Apakah nombor CAS dan formula molekul bagi Nilotinib & its intermediates?
CAS 641571-10-0; formula molekul C28H22F3N7O; berat molekul — g/mol.
Apakah nama lain yang Nilotinib & its intermediates diketahui oleh?
Nilotinib, 641571-10-0, AMN 107, AMN-107, nilotinibum, Danziten.
Adakah Nilotinib & its intermediates dikelaskan sebagai berbahaya?
Kenyataan bahaya dilaporkan: H361, H372, H373, H400, H410.
Apakah sifat fizikal utama bagi Nilotinib & its intermediates?
Keterlarutan: 2.01e-03 g/L; Dissociation Constants: pKa1 = 2.1; pKa2 = 5.4.
Fakta di halaman ini diambil daripada PubChem (Perpustakaan Perubatan Negara AS) dan Wikidata. Data khusus gred — ujian, lembapan, saiz zarah, pembungkusan, jangka hayat — dikeluarkan setiap kelompok pada COA dan tidak diterbitkan di sini.
Aplikasi dan bidang penggunaan
Nilotinib & perantaraannya (CAS 641571-10-0, formula C28H22F3N7O, jisim molar 529.5 g/mol) terutamanya digunakan dalam sintesis kimia, bahan kimia halus dan proses industri berkaitan. Spesifikasi, COA dan harga pukal Nilotinib & perantaraannya disediakan oleh pasukan jualan kami.
Produk serupa dalam kategori yang sama
Packaging & Shipping
- Standard: 25 kg fiber drum / 200 kg steel drum with double PE liner
- Small pack: 1 kg / 5 kg aluminum foil bag for lab & sample
- Custom: packaging size and labeling per customer requirement
- Lead time: in-stock items ship within 3-5 business days
- Documents: COA, MSDS / SDS, TDS provided with every shipment
- Global: air, sea (FCL / LCL) and express to 80+ countries
Storage & Handling
Store in a cool, dry, well-ventilated place away from heat, direct sunlight and incompatible materials. Keep container tightly closed. Use appropriate personal protective equipment and refer to the SDS for full safety guidance before handling.
Frequently Asked Questions
Yes. A batch-specific COA and free or charged sample are available on request before bulk ordering.
Yes. We offer custom grade, particle size and purity adjustment based on your application and order volume.
MOQ depends on the product; small quantities are supported for R&D and trial runs.
Every batch is tested in-house and retains full traceability from raw material to finished goods.
Why Choose Jinan Shenghe Chemical
Request a Quote
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About Jinan Shenghe Chemical Co., Ltd.
Jinan Shenghe Chemical Co., Ltd.
We are a professional chemical supplier based in Jinan, China. Since 2013, we have been connecting manufacturers and global B2B buyers with reliable sourcing, quality-controlled products and efficient logistics.
Our business covers food & feed additives, fine chemicals, pharmaceutical intermediates, eco-materials, coatings and specialty chemicals — all non-hazardous and compliant with our licensed scope.